Study on Use of CBD-Rich Products for Anxiety, Pain and Depression

CBD is one of the over 60 cannabinoids or naturally-occurring chemicals found in industrial hemp and marijuana. Cannabinoids interact with the body’s endocannabinoid system (ECS), which is made up of endocannabinoids or neurotransmitters that send chemical messages between neurons, the cells that transmit nerve impulses. The ECS has CB1 and CB2 cannabinoid receptors. CB1 receptors are mostly located in the brain; CB2 receptors are mostly found in immune cells and in a few neurons.[1]

 The ECS acts to restore balance whenever something happens with one of the body functions, such as appetite, sleep, immune response, and more.  When CBD interacts with the CB2 receptor, it inhibits pain and inflammation. It also releases tension that causes anxiety.


CBD’s Effectiveness as Add-On Therapy

A team of Canadian researchers conducted a study on the long-term use of CBD-rich cannabis products to determine their effectiveness in improving the condition of patients with moderate to severe anxiety, pain and depression.

 Of the purpose of the study, researchers said that the potential of CBD as an add-on therapy has been studied for a number of conditions, including social anxiety, non-motor Parkinson’s, schizophrenia and substance abuse. However, there has been limited evidence of CBD’s effectiveness for other than pediatric epilepsy.

 In conducting the research, which was published in the Journal of Cannabis Research, researchers evaluated the use of lab-tested CBD-rich products over six months by 279 participants who had mild to severe symptoms. They administered the CBD-rich products in various methods and formats, but most commonly as oral plant-derived extracts or oils and as inhaled dried flowers.


Study results

The research indicated that patients with more severe symptoms exhibited clinical benefits following the use of CBD. However, subjects with mild symptoms experienced little overall change in their symptoms.

 Researchers said that their study on CBD-rich products “…demonstrates the potential of RWE (real-world evidence) for the advancement of medical cannabis research and practice guidelines, especially in a world where CBD use is exponentially increasing but scientific data are limited. “



Full text of study:  Cannabidiol use and effectiveness: Real-world evidence from a Canadian medical cannabis clinic,” appears in the Journal of Cannabis Research.
Rapin, L., Gamaoun, R., El Hage, C. et al. Cannabidiol use and effectiveness: real-world evidence from a Canadian medical cannabis clinic. J Cannabis Res 3, 19 (2021).
[1] Mackie K. Cannabinoid receptors: where they are and what they do. J Neuroendocrinol. 2008 May;20 Suppl 1:10-4. doi: 10.1111/j.1365-2826.2008.01671.x. PMID: 18426493.